EPHT FUMARATE MECHANISM OF ACTION AND THERAPEUTIC POTENTIAL

Ept fumarate functions by inhibiting the enzyme prolyl hydroxylase domain containing proteins (PHD), which are involved in the regulation of hypoxia-inducible factor 1α (HIF-1α). This inhibition leads to the stabilization and enhancement of HIF-1α, a transcription factor that regulates the expression of genes involved in cellular response to low